New Cdc25B tyrosine phosphatase inhibitors, nocardiones A and B, produced by Nocardia sp. TP-A0248: taxonomy, fermentation, isolation, structural elucidation and biological properties

*Toshio Otani, Yoshikazu Sugimoto, Yoshimi Aoyagi, **Yasuhiro Igarashi, **Tamotsu Furumai, Noriko Saito, Yuji Yamada, Tetsuji Asao, and Toshikazu Oki   *Hanno Research Center, Taiho Pharmaceutical Co., Ltd., **Biotechnology Research Center, Toyama Prefectural University, ***National Institute of Infectious Diseases

J. Antibiotics, 53(4), 337-344, 2000.

        Strain TP-A0248 which produces two new Cdc25B tyrosine phosphatase inhibitors and also prossessing antifungal activity, designated nocardiones Ａ(1) and B(2), was considered to properties. The nocardiones were isolated by solvent extraction of fermentation broth of Nocardia sp. TP-A0248 and purified by the conventional column chromatography.  Spectroscopic studies led to determination that 1 and 2 belong to a class compound of naphtho[1,2-b]furan-4,5-diones.  Compound 1 inhibited the activity of Cdc25B, PTP1B and FAP-1 protein tyrosine phosphatases at a concentration of 10 μM. It also showed moderate in vitro antifungal and cytotoxic activity.

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