New Cdc25B tyrosine phosphatase inhibitors, nocardiones A and B, produced by Nocardia sp. TP-A0248: taxonomy, fermentation, isolation, structural elucidation and biological properties

*Toshio Otani, Yoshikazu Sugimoto, Yoshimi Aoyagi, **Yasuhiro Igarashi, **Tamotsu Furumai, Noriko Saito, Yuji Yamada, Tetsuji Asao, and Toshikazu Oki   *Hanno Research Center, Taiho Pharmaceutical Co., Ltd., **Biotechnology Research Center, Toyama Prefectural University, ***National Institute of Infectious Diseases

J. Antibiotics, 53(4), 337-344, 2000.

        Strain TP-A0248 which produces two new Cdc25B tyrosine phosphatase inhibitors and also prossessing antifungal activity, designated nocardiones `(1) and B(2), was considered to properties. The nocardiones were isolated by solvent extraction of fermentation broth of Nocardia sp. TP-A0248 and purified by the conventional column chromatography.  Spectroscopic studies led to determination that 1 and 2 belong to a class compound of naphtho[1,2-b]furan-4,5-diones.  Compound 1 inhibited the activity of Cdc25B, PTP1B and FAP-1 protein tyrosine phosphatases at a concentration of 10 M. It also showed moderate in vitro antifungal and cytotoxic activity.

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