New Cdc25B tyrosine phosphatase inhibitors, nocardiones A and B, produced by Nocardia sp. TP-A0248: taxonomy, fermentation, isolation, structural elucidation and biological properties
*Toshio Otani, Yoshikazu Sugimoto, Yoshimi Aoyagi, **Yasuhiro Igarashi, **Tamotsu Furumai, Noriko Saito, Yuji Yamada, Tetsuji Asao, and Toshikazu Oki *Hanno Research Center, Taiho Pharmaceutical Co., Ltd., **Biotechnology Research Center, Toyama Prefectural University, ***National Institute of Infectious Diseases
J. Antibiotics, 53(4), 337-344, 2000.
Strain TP-A0248 which produces two new Cdc25B tyrosine phosphatase inhibitors and also prossessing antifungal activity, designated nocardiones ‚`(1) and B(2), was considered to properties. The nocardiones were isolated by solvent extraction of fermentation broth of Nocardia sp. TP-A0248 and purified by the conventional column chromatography. Spectroscopic studies led to determination that 1 and 2 belong to a class compound of naphtho[1,2-b]furan-4,5-diones. Compound 1 inhibited the activity of Cdc25B, PTP1B and FAP-1 protein tyrosine phosphatases at a concentration of 10 ƒÊM. It also showed moderate in vitro antifungal and cytotoxic activity.Go back to the list of publication
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