Novel triene-beta-lactone antibiotics, oxazolomycin derivatives and its isomer, produced by Streptomyces sp. KSM-2690

***Toshio Otani, Ken-ichiro Yoshida, Hiromi Kubota, Shuji Kawai, Susumu Ito, **Hiroshi Hori, **Tadayuki Ishiyama and Toshikazu Oki  *Research institute, Tamagawa University, **Faculty of Agriculture, Tamagawa University, ***Tokushima Research Center, Taiho Pharmaceutical Co., Ltd., ü¸Tochigi Research laboratories, Kao Corporation

J. Antibiotics, 53(12): 1397-1400, 2000

        In the course of our screening for novel antibacterial antibiotics produced by microorganisms, a strain termed KSM-2690 was found to produce a new complex of triene-â└-lactone antibiotics in the culture filtrate. The active principle was recovered from the broth filtrate with ethyl acetate extraction and could e divided into six components, three major components KSN-2690 A (1), B (2) and C (3), and three minor components KSM-2690 D, E and F, on the basis of their respective order of elution under the reverse-phase HPLC. The characteristic UV and IR spectra of their components were similar to those of oxazolomycins, indicating that these new compounds are members of the triene-â└-lactone group of antibiontics. Among them, the new antibiotics 2 and 3 presented here were an additional member of this group and its isomer, as shown in the gross structures.   They showed anti-Gram positive activity and weak cytotoxicity against human bladder carcinoma T24 cells.

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