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  • 児童期(12歳まで)に運動経験を有する人は後年の認知機能が高いことが示されました。
  • 一方で、思春期以降の運動経験と認知機能の間に関係は認められませんでした。
  • 児童期の運動経験と認知機能の関係は、脳内ネットワークのモジュール※1分離、左右半球間の構造的結合の強化、皮質の厚さの増大、神経突起のちらばりと密度の減少によるものであることが示唆されました。
  • 環境や経験に依存した脳内ネットワークの形成に敏感な児童期に運動を行うことで、脳内ネットワークの最適化が促され、後年の認知機能の維持・増進につながると考えられます。

<掲載論文名>Childhood exercise predicts response inhibition in later life via changes in brain connectivity and structure
<著者名>Toru Ishihara, Atsushi Miyazaki, Hiroki Tanaka, Takayuki Fujii, Muneyoshi Takahashi, Kuniyuki Nishina, Kei Kanari, Haruto Takagishi & Tetsuya Matsuda
<掲載誌>NeuroImage (DOI:10.1016/j.neuroimage.2021.118196)



  • 有酸素性の持久力と手指の巧緻性は、互いに独立してワーキングメモリーとポジティブに関わることが示されました。一方で、歩行速度と筋力にはそのような関係は認められませんでした。
  • 持久力が高い人は、課題中の前頭―頭頂ネットワークの活動を上昇させること、また、その領域の活動が十分でない場合には、より広範な領域の活動を上昇させることで、ワーキングメモリー課題の成績を向上させていることが示されました。
  • 手指の巧緻性が高い人は、課題中の前頭―頭頂ネットワークの活動を上昇させ、デフォルトモードネットワークの活動を低下させること、また、それらのネットワーク間の関係を調節することで、ワーキングメモリー課題の成績を向上させていることが示されました。

<掲載論文名>Identification of the brain networks that contribute to the interaction between physical function and working memory: an fMRI investigation with over 1,000 healthy adults
<著者名>Toru Ishihara, Atsushi Miyazaki, Hiroki Tanaka, & Tetsuya Matsuda
<掲載誌>NeuroImage(DOI: 10.1016/j.neuroimage.2020.117152)

Publication list



  • Ishihara T, Miyazaki A, Tanaka H, Fujii T, Takahashi M, Nishina K, Kanari K, Takagishi H, Matsuda T*. Childhood exercise predicts response inhibition in later life via changes in brain connectivity and structure. Neuroimage 2021 237:118196. doi: 10.1016/j.neuroimage.2021.118196.


  • Ishihara T, Miyazaki A, Tanaka H, Matsuda T*. Identification of the brain networks that contribute to the interaction between physical function and working memory: An fMRI investigation with over 1,000 healthy adults. Neuroimage 2020 221: 117152. doi: 10.1016/j.neuroimage.2020.117152.


  • Xu J, Zommara MN, Ounjai K, Takahashi M, Kobayashi S, Matsuda T, Lauwereyns J. Urgency promotes affective disengagement: Effects from bivalent cues on preference formation for abstract images. Frontiers in Psychology 2020 11:1404. doi: 10.3389/fpsyg.2020.01404.


  • Wolf A, Ounjai K, Takahashi M, Kobayashi S, Matsuda T, Lauwereyns J. Evaluative Processing of Food Images: Longer Viewing for indecisive preference formation. Frontiers in Psychology 2019 10:608. doi: 10.3389/fpsyg.2019.00608.


  • Ounjai K, Kobayashi S, Takahashi M, Matsuda T, Lauwereyns J. Active Confirmation Bias in the Evaluative Processing of Food Images. Rep. 2018 8(1): 16864. doi: 10.1038/s41598-018-35179-9.


  • Wolf A, Ounjai K, Takahashi M, Kobayashi S, Matsuda T, Lauwereyns J. Evaluative Processing of Food Images: A Conditional Role for Viewing in Preference Formation. Frontiers in Psychology 2018 9: 936. doi:10.3389/fpsyg.2018.00936


  • Takasue H, MiyauchiCM, Sakaiya S, Fan H, Matsuda T, Kato J. Human pursuance of equality hinges on mental processes of projecting oneself into the perspectives of others and into future situations. Sci. Rep. 2017 7(1):5878. doi:10.1038/s41598-017-05469-9.


  • Kameda T, Inukai K, Higuchi S, Ogawa A, Kim H, Matsuda T, Sakagami M. Rawlsian maximin rule operates as a common cognitive anchor in distributive justice and risky decisions. PNAS 2016 113(42):11817-11822. doi: 10.1073/pnas.1602641113


  • Nakagawa J, Takahashi M, Okada R, Matsushima E, Matsuda T*. Women's Preference for a Male Acquaintance Enhances Social Reward Processing of Material Goods in the Anterior Cingulate Cortex. PLoS ONE, 2015 10(8): e0136168


  • Okada R, Nakagawa J, Takahashi M, Kanaka N, Fukamauchi F, Watanabe K, Namatame M, Matsuda T*. The deaf phonological representations in visually presented verbal memory tasks. Neurosci. Res. 2015, 90, 83-90.


  • Ito T, Matsuda T*, Shimojo S. Functional Connectivity of the Striatum in Experts of Stenography. Brain and Behavior. 2015, 5(5), e00333. DOI: 10.1002/brb3.333.


  • Takahashi H, Matsuda T. A critical evaluation of current social neuroscience knowledge and new directions in understanding social behavior. Neurosci, Res. 2015. 90, 1-2.


  • Kanero J, Imai M, Okuda J, Okada H, Matsuda T*. How sound symbolism is processed in the Brain: A study on Japanese Mimetic words. PLoS ONE. 2014, 9(5), e97905.


  • Ito T, Wu DA, Marutani T, Yamamoto M, Suzuki H, Shimojo S, Matsuda T*. Changing the mind? Not really activity and connectivity in the caudate correlates with changes of choice. Soc Cogn Affect Neurosci. 2014, 9(10), 1546-1551. doi: 10.1093/scan/nst147.


  • Yamada M, Camerer CF, Fujie S, Kato M, Matsuda T, Takano H, Ito H, Suhara T, Takahashi H. Neural circuits in the brain that are activated when mitigating criminal sentences. Nature Communications. 2012, 3, 759.


  • Hsu DF, Ito T, Schweikert C, Matsuda T, Shimojo S. Combinatorial Fusion Analysis in Brain Informatics: Gender Variation in Facial Attractiveness Judgment. Brain Informatics Lecture Note in Computer Science. 2011, 6889, 2-20.


  • Watanabe K, Matsuda T, Nishioka T, Namatame M. Eye gaze during observation of static faces in deaf people. PloS ONE. 2011, 6(2), 216919.


  • Marutani T, Yahata N, Ikeda Y, Ito T, Yamamoto M, Matsuura M, Matsushima E, Okubo Y, Suzuki H, Matsuda T*. Functional magnetic resonance imaging study on the effects of acute single administration of paroxetine on motivation-related brain activity. Psychiatry and Clin. Neurosci. 2011, 65(2), 191-198.


  • Motoshita M, Matsuura M, Ohkubo T, Ohkubo H, Kanaka N, Matsushima E, Taira M, Kojima T, Matsuda T*. Hyperfrontality in patients with schizophrenia during saccade and antisaccade tasks: a study with fMRI. Psychiatry and Clin. Neurosci. 2009, 63(2), 209-217.


  • Abe N, Okuda J, Suzuki M, Sasaki H, Matsuda T, Mori E, Tsukada M, Fujii T. Neural correlates of true memory, false memory, and deception. Cerebral Cortex, 2008, 18(12), 2811-2819.


  • Kanaka N, Matsuda T*, Tomimoto Y, Noda Y, Matsushima E, Matsuura M, Kojima T. Measurement of development of cognitive and attention functions in children using continuous performance test. Psychiatry and Clin. Neurosci. 2008, 62, 135-141.


  • Takahashi H, Yahata N, Koeda M, Matsuda T, Asai K, Okubo Y. Brain activation associated with evaluation process of guilt and embarrassment: an fMRI study. NeuroImage, 2004, 23, 967-974.


  • Matsuda T*, Matsuura M, Ohkubo T, Ohkubo H, Matsushima E, Inoue K, Taira M, Kojima T. Functional MRI mapping of brain activation during visually guided saccades and antisaccades: cortical and sub-cortical networks. Psychiatry Research: Neuroimaging, 2004, 131, 147-155.


  • Takahashi H, Koeda M, Oda K, Matsuda T, Matsushima E, Matsuura M, Asai K, Okubo Y. An fMRI study of differential neural response to affective pictures in schizophrenia. Neuroimage, 2004, 22, 1247-1254.


  • Watanabe M, Matsuura M, Sano T, Matsuda R, Matsuda T and Kojima T. Daytime sleepiness in hypersomniac patients, epileptic patients, and in healthy subjects. Sleep and Biological Rhythms, 2003, 1, 137-138.


  • Oda K, Ohkubo Y, Ishida R, Murata Y, Ohta K, Matsuda T, Matsushima E, Ichimiya T, Suhara T, Shibuya H, and Nishikawa T. Regional Cerebral Blood Flow in Depressed Patients with White Matter Magnetic Resonance Hyperintensity. Biological Psychiatry, 2003, 53, 150-156.


  • Matsuda T*, Matsuura M, Ohkubo T, Ohkubo H, Atsumi Y, Tamaki M, Takahashi K,   Matsushima E, Kojima T. Influence of arousal level for functional magnetic resonance imaging(fMRI) study: Simultaneous recording of fMRI and electroencephalogram. Psychiatry and Clinical Neuroscience, 2002, 56, 289-290.


  • Suzuki H, Matsuura M, Moriguchi K, Kojima T, Hiroshige Y, Matsuda T, Noda Y. Two auto-detection methods for eye movements during eye closed. Psychiatry and Clinical Neuroscience. 2001:55:197-198.


  • Suzuki H, Moriguchi K, Matsuura M, Kojima T, Matsuda T, Noda Y, Minemura H, Yamamoto H, Akashiba T, Horie T. Two nap sleep test-An easy objective sleepness test: Psychiatry and Clinical Neuroscience. 54:285-286,2000